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FStox consulting provides class leading expertise in computational chemistry including read across. Genetic toxicology (OECD and GLP compliant regulatory in vitro and in vivo genetic toxicity tests) as well as interpretation of carcinogenicity data, modelling and setting acceptable limits. We also have experience of risk assessing natural substances (i.e. botanicals).
We have a combined experience of over 40 years across various toxicology disciplines.
Preparation of literature reviews
Steering of pre-clinical regulatory genetic toxicology packages (ICH S2R1)
Placing and monitoring of studies at CRO's
Modelling carcinogenicity data (setting acceptable levels)
Assessment of genotoxic pharmaceutical impurities (ICH M7)
Defining strategies for genetic toxicology testing programmes, screening etc.
Interpretation and commissioning of bespoke investigative studies to identify mode of action and relevance to human health.
Expert interpretation of existing data sets.
Application of in silico tools (DEREK, OECD toolbox, Toxtree etc) for prediction of mutagenicity.
Read across approaches for materials without existing data sets.
REACH requirements for submission of genetic toxicology data
News & Publications
Paul Fowler has joined the UK Committee on Mutagenicity (COM) from September 2019
FStox has recently co-authored a review of the genotoxicity of TMPTA published in Mutation Research, see HERE for details
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WE ARE HERE TO HELP YOU PROGRESS YOUR MATERIAL THROUGH SAFETY AND REGULATORY ASSESSMENT
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